Chromatin Conformation and Gene Expression Regulation
Using CAP-C technology, the resolution limitations of traditional techniques are overcome to explore the interactions between genes and within genes, deciphering the relationship between structural variations, chromatin interactions, and gene expression.
Post-Transcriptional Gene Expression Regulation
Using RNA structurome and polysome profiling techniques to analyze the differences in RNA secondary structure among homologous genes in vivo and their contribution to translation, investigating the molecular mechanisms of subgenome adaptability at the translation level.
Gene Stability and Genome Evolution at the Polyploid Chromosome Level
Based on GISH and FISH chromosome identification to detect changes in chromosome number and structure, an integrated wheat genus karyotyping technique is established and utilized. By observing chromosome behavior during meiosis with a high-resolution microscope, the phenomenon of “extensive chromosome number variation in the early formation of hexaploid wheat” is first discovered.
